Protein Modification Reagents
![eMolecules bis-PEG2-endo-BCN | Broadpharm | 1476737-97-9 | MFCD19705423 | 500.636 | C28H40N2O6 | 97.000 | O=C(NCCOCCOCCNC(=O)OC[C@@H]1[C@@H]2CCC#CCC[C@H]12)OC[C@@H]1[C@@H]2CCC#CCC[C@H]12 | 50mg | 340377180](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC1737768.jpg-250.jpg)
eMolecules bis-PEG2-endo-BCN | Broadpharm | 1476737-97-9 | MFCD19705423 | 500.636 | C28H40N2O6 | 97.000 | O=C(NCCOCCOCCNC(=O)OC[C@@H]1[C@@H]2CCC#CCC[C@H]12)OC[C@@H]1[C@@H]2CCC#CCC[C@H]12 | 50mg | 340377180
bis-PEG2-endo-BCN | Broadpharm | 1476737-97-9 | MFCD19705423 | 500.636 | C28H40N2O6 | 97.000 | O=C(NCCOCCOCCNC(=O)OC[C@@H]1[C@@H]2CCC#CCC[C@H]12)OC[C@@H]1[C@@H]2CCC#CCC[C@H]12 | 50mg | 340377180
eMolecules 35164-96-6 | Tos-PEG21-Tos | Broadpharm | MFCD30458052 | 1207.440 | C54H94O25S2 | 95.000 | Cc1ccc(cc1)S(=O)(=O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOS(=O)(=O)c1ccc(C)cc1 | 1g | 311074443
Tos-PEG21-Tos | Broadpharm | 35164-96-6 | MFCD30458052 | 1207.440 | C54H94O25S2 | 95.000 | Cc1ccc(cc1)S(=O)(=O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOS(=O)(=O)c1ccc(C)cc1 | 1g | 311074443
eMolecules 2055042-60-7 | N-(Boc-PEG3)-N-bis(PEG2-alcohol) | Broadpharm | MFCD30182039 | 556.694 | C25H52N2O11 | 97.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCN(CCOCCOCCO)CCOCCOCCO | 500mg | 309208953
N-(Boc-PEG3)-N-bis(PEG2-alcohol) | Broadpharm | 2055042-60-7 | MFCD30182039 | 556.694 | C25H52N2O11 | 97.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCN(CCOCCOCCO)CCOCCOCCO | 500mg | 309208953
Medchemexpress LLC PEG5-Tos | 155130-15-7 | 96.9% | 392.46 | 1 G
PEG5-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs (Proteolysis Targeting Chimeras) consist of two different ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets the protein of interest. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- For research use only
Medchemexpress LLC Azide-PEG5-Tos | 236754-49-7 | MFCD28505520 | >98.0% | 417.48 | C17H27N3O7S | 25 G
Azide-PEG5-Tos is an azide-functional polyethylene glycol (PEG) linker consisting of five ethylene glycol units and a tosylate leaving group. It is designed for bioconjugation applications such as antibody-drug conjugate (ADC) synthesis and click chemistry, and is supplied for research use only.
- Cleavable 5-unit PEG linker suitable for ADC and PROTAC synthesis.
- Azide functional group enables copper-catalyzed and strain-promoted azide-alkyne cycloaddition.
- High solubility in DMSO (≥100 mg/mL) and compatible with common in vivo vehicles at ≥2.5 mg/mL.
- Tosylate leaving group allows for further nucleophilic substitution reactions.
- Recommended storage: pure solid at -20°C (long term) or 4°C (short term).
eMolecules m-PEG8-BBTA | Broadpharm |742.840 | C36H46N4O11S | 95.000 | COCCOCCOCCOCCOCCOCCOCCOCCC(=O)Nc1ccc2nc(oc2c1)-c1ccc(s1)-c1nc2ccc(N)cc2o1 | 1mg | 518001028
m-PEG8-BBTA | Broadpharm |742.840 | C36H46N4O11S | 95.000 | COCCOCCOCCOCCOCCOCCOCCOCCC(=O)Nc1ccc2nc(oc2c1)-c1ccc(s1)-c1nc2ccc(N)cc2o1 | 1mg | 518001028
Cayman Chemical XnthIn amIn congenr 10mg
A non-selective adenosine receptor antagonist (Kbs = 83, 25, and 15 nM for rat PC 12 cells, human platelets, and rat fat cells, respectively); reduces NECA-stimulated adenylate cyclase activity in human platelets (EC50s = 1 and 0.31 μM in the presence and absence of XAC, respectively); reverses R-PIA-induced inhibition of isoproterenol-stimulated adenylate cyclase activity in rat fat cell membranes (IC50s = 146 and 26 nM in the presence and absence of XAC, respectively); reverses 2-CADO-, R-PIA-, and NECA-induced reductions in heart rate and blood pressure in rats (0.1-1.0 mg/kg); induces convulsions in mice (39.8 mg/kg)
Medchemexpress LLC Mal-PEG8-Val-Cit-PAB-MMAF | 100.0% | 1640.95 | C81H129N11O24 | 5 MG
Mal-PEG8-Val-Cit-PAB-MMAF is a drug-linker conjugate used in antibody-drug conjugate (ADC) research. It couples the tubulin inhibitor MMAF to a cleavable Val-Cit-PAB peptide linker via an 8-unit PEG spacer and a maleimide reactive group, enabling site-selective conjugation and protease-triggered payload release.
- Cleavable Val-Cit-PAB peptide linker enables protease-triggered payload release.
- Maleimide reactive group for cysteine-directed conjugation.
- PEG8 spacer improves solubility and reduces steric hindrance.
- High purity suitable for research applications.
- Molecular weight 1640.95, molecular formula C81H129N11O24.
- Available in small-mass packs suitable for ADC synthesis and development.
Medchemexpress LLC Me-tet-peg4-cooh | 2141976-30-7 | 98.7% | 477.51 g·mol⁻¹ | C22H31N5O7 | 10 MG
Me-Tet-PEG4-COOH is an ADC linker containing four polyethylene glycol (PEG) units and a tetrazine group that enables inverse electron demand Diels-Alder (iEDDA) bioorthogonal conjugation with TCO-containing partners. Intended for research use in bioconjugation and ADC development.
- Purity: 98.68%
- Molecular weight: 477.51 g·mol⁻¹
- Chemical formula: C22H31N5O7
- Cas number: 2141976-30-7
- Appearance: pale purple to purple solid
- Solubility: DMSO 125 mg/mL (requires ultrasonic; use newly opened DMSO)
- Storage: powder -20°C up to 3 years; in solvent -80°C for 6 months, -20°C for 1 month
- Product type: ADC linker
Medchemexpress LLC Boc-N-Amido-PEG4-propargyl | 1219810-90-8 | 99.7% | C16H29NO6 | 100 MG
Boc-N-Amido-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. PROTACs themselves contain two different ligands connected by a linker; one ligand is for an E3 ubiquitin ligase, and the other for the target protein, enabling PROTACs to exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Peg-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an Alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
Medchemexpress LLC Dope-peg-mal | 98.2% | 2000 Da | 5 MG
DOPE-PEG-Mal (MW 2000) is a maleimide-functionalized dioleoyl phosphoethanolamine-polyethylene glycol conjugate formulated for liposome and nanoparticle preparation and for covalent attachment to thiol-containing ligands. The maleimide group enables rapid, selective thiol coupling under mild conditions to yield stable thioether linkages; the PEG moiety (average MW ~2000 Da) provides steric stabilization in formulations.
- Maleimide-functionalized lipid for thiol conjugation.
- Selective thiol reactivity at pH 6.5-7.5 forming stable thioether bonds.
- Suitable for liposome and nanoparticle formulation.
- Average PEG molecular weight ~2000 Da for steric stabilization.
- High reported purity (≈98.2%).
- Available in small research pack sizes for formulation work.
Medchemexpress LLC Tco-peg8-nhs ester | 2353409-95-5 | 95.0% | C32H54N2O14 | 10MG
TCO-PEG8-NHS ester is a PEG-based PROTAC linker with an N-hydroxysuccinimide (NHS) activated ester that enables efficient conjugation to primary amines. The molecule incorporates a trans-cyclooctene (TCO) moiety separated by an eight-unit PEG spacer to provide aqueous solubility and flexible spacing for bioconjugation and targeted protein degradation construct synthesis.
- NHS-activated ester for efficient amide bond formation.
- Eight-unit PEG spacer improves solubility and flexibility.
- Provides a trans-cyclooctene (TCO) handle for click chemistry.
- High reported purity (95.0%).
- Supplied in small-mass packages suitable for research use.
![eMolecules 2226472-38-2 | endo-BCN-PEG4-acid | Broadpharm | MFCD23704190 | 441.521 | C22H35NO8 | 97.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)OC[C@@H]1[C@@H]2CCC#CCC[C@H]12 | 100mg | 204725189](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC1763703.jpg-250.jpg)
eMolecules 2226472-38-2 | endo-BCN-PEG4-acid | Broadpharm | MFCD23704190 | 441.521 | C22H35NO8 | 97.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)OC[C@@H]1[C@@H]2CCC#CCC[C@H]12 | 100mg | 204725189
endo-BCN-PEG4-acid | Broadpharm | 2226472-38-2 | MFCD23704190 | 441.521 | C22H35NO8 | 97.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)OC[C@@H]1[C@@H]2CCC#CCC[C@H]12 | 100mg | 204725189